Post-COVID-19 long term impact on lung function and quality of life: who should be concerned?

Author:

Toh Ming Ren1,Teo Rachel1,Poh Ruby1,Tang Yiting1,Soh Rui Ya1,Sharma Kiran1,Poh Kai Chin1,Kalyanasundaram Ganesh1

Affiliation:

1. Sengkang General Hospital

Abstract

Abstract Post-COVID-19 pulmonary sequalae are well-recognized early in the pandemic. Survivorship clinics are crucial for managing at-risk patients. However, it is unclear who requires pulmonary function test (PFT) and when PFTs should be performed. We aim to investigate for whom and how these interval PFTs should be performed. We performed a single-centre, prospective cohort study on COVID-19 survivors between 1st May 2020 to 31st April 2022. These patients were followed up at 6, 9 and 12 months with interval PFT and Short Form-36 (SF-36) Health Survey. Those with PFT defects were offered a computed tomography scan of the thorax. Of the 46 patients recruited, 17 (37%) had severe/critical illness. Compared to those with mild/moderate disease, these patients were more likely to experience DLCO defects (59% versus 17%, p = 0.005) and had lower SF-36 scores (mean physical component summary score of 45 ± 12 versus 52 ± 8, p = 0.046). These differences were most notable at 6 months, compared to the 9- and 12-months intervals. DLCO defects were also associated with older age, raised inflammatory markers and extensive CXR infiltrates. Besides interstitial-like abnormalities, obesity and undiagnosed lung conditions accounted for 39% of the PFT abnormalities. Interval PFTs can be performed earliest 6 months post-COVID-19. Patients with normal tests were unlikely to develop new abnormalities and would not require repeat PFTs. Abnormal PFTs can be followed-up with repeat PFTs 6 monthly until resolution. Non-COVID-19 differentials should be considered for persistent PFT abnormalities.

Publisher

Research Square Platform LLC

Reference46 articles.

1. WHO. WHO Coronavirus (COVID-19) Dashboard. https://covid19.who.int. Date last updated: June 7 2023. Date last accessed: June 11 2023.

2. COVID-19 disease severity in US Veterans infected during Omicron and Delta variant predominant periods;Mayr FB;Nature Communications,2022

3. Severity of COVID-19 cases in the months of predominance of the Alpha and Delta variants;Florensa D;Scientific Reports,2022

4. COVID-19 severity from Omicron and Delta SARS-CoV-2 variants;Wrenn JO;Influenza and Other Respiratory Viruses,2022

5. Factors associated with impaired quality of life three months after being diagnosed with COVID-19;Rass V;Quality of Life Research,2022

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