Association of Inflammatory Cells to High-density Lipoprotein Cholesterol ratio with Acute Pulmonary Embolism

Abstract

AbstractPurpose Aim of this study was to investigate the effectiveness of neutrophil, monocyte and lymphocyte to HDL- cholesterol ratio in people diagnosed with acute pulmonary embolism for predict pulmonary embolism related adverse clinical events (PEACE). Methods Retrospective collected the date of total 215 patients diagnosed with pulmonary embolism. Laboratory results of leukocyte, biochemical and cardiac markers were collected. Pulmonary Embolism Severity Index (PESI), ratio of neutrophil, monocyte and lymphocyte count to high-density lipoprotein cholesterol (HDL) were calculated. SPSS 25 was used for evaluating the effectiveness of NHR MHR and LHR in predicting PEACE. Results Patients who suffered clinical adverse events had higher MHR and NHR value and lower LHR value. In multivariate regression analysis, PESI scores (OR: 1.041 95% CI: 1.024 ~ 1.059, p < 0.01), MHR value (OR: 1.053 95% CI: 3.25–52.64, p < 0.01), NHR value (OR: 1.332 95% CI: 1.020 ~ 1.740, P = 0.035), and N-terminal pro-brain natriuretic peptide (OR: 1.203 95% CI: 1.036 ~ 1.397, P = 0.015) were independent predictors of PEACE. Conclusion We think that MHR and NHR value can be used as useful indicators to identify early clinical adverse events in patients with acute pulmonary embolism