Lower serum CTRP3 is related to more severe distal symmetric polyneuropathy in type 2 diabetic patients

Author:

Han Pingping1,Hu Fan1,Guo Jia1,Xu Leirui1,Zhang Junxia2

Affiliation:

1. Central Theatre General Hospital: PLA Central Military Command General Hospital

2. Taikang Tongji (Wuhan)Hospital

Abstract

Abstract

Background: Distal symmetric polyneuropathy (DSPN) is one of the most common chronic complications in patients with type 2 diabetes mellitus (T2DM). Our previous study found that serum C1q tumor necrosis factor-related protein 3 (CTRP3) levels were decreased in type 2 diabetic patients. Thus, this study was designed to reveal the relationship between lower serum CTRP3 and the prevalence and severity of DSPN. Methods: A total of 178 cases of patients with T2DM were enrolled in the study. The subjects were divided into DSPN group (n=89) and non-DSPN group (n=89). Both the anthropometric parameters and neurologic symptoms were recorded. Also, neurologic signs, neuropathy symptom score (NSS) and neuropathy disability score (NDS) were measured. Biochemical indexes, fasting insulin, and C peptide were detected. Serum CTRP3 concentrations were assayed by ELISA method. Results: Serum CTRP3 levels decreased significantly in DSPN group compared with non-DSPN group (P<0.05). CTRP3 was negatively associated with the number of positive signs, NSS score, and NDS score in patients with DSPN (all P<0.05). Interestingly, the higher the score of NSS or NDS, the lower the levels of serum CTRP3 (all P<0.05). Moreover, the patients with lower CTRP3 levels (<7.58ng/ml) had higher positive rate of neurologic signs (all P<0.05). Binary logistic regression analysis showed that CTRP3 independently predicted the occurrence of DSPN (β= -0.316, P<0.001). ROC curve analysis displayed that the best cut-off value of CTRP3 for the prediction of DSPN was 7.55ng/ml (sensitivity 78.7%, specificity 79.8%), and the area under the curve (AUC) was 0.763 (95% CI 0.689-0.838, P<0.001). Conclusion: Lower serum CTRP3 is a strong predictor for the occurrence and progression of DSPN in Chinese patients with T2DM.

Publisher

Springer Science and Business Media LLC

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3