Dual-layer Spectral Detector CT in Predicting Benign and Malignant Laryngeal Tumors

Abstract

Abstract Objectives: To investigate the quantitative parameters of dual-layer spectral detector CT in the assessment of benign and malignant laryngeal tumors. Methods: Spectral images of 47 patients were retrospectively analyzed in both the arterial phase (AP) and the venous phase (VP), including 26 larynx squamous carcinoma (LSCC) lesions and 28 benign lesions. For the 54 lesions in the AP and VP, the slope of the spectral curve (λHUa and λHUv) from 40keV to 90keV, CT values of conventional images (CTa and CTv), iodine concentrations (ICa and ICv), normalized IC (NICa and NICv), effective atomic number (Zeff-a and Zeff-v), and normalized Zeff (nZeff-a and nZeff-v) were calculated and analyzed between LSCC and benign patients. ROC curve, independent sample t-test, and Spearman rank-sum test were used in statistical analysis. Results: λHUv40-60keV had the highest diagnostic efficiency in all slope of the spectral curve. So λHU40-60keV was the best slope. All parameters in AP didn’t have well identifying efficiency. But all parameters in VP had perfect identifying efficiency. Especially the ICv was the highest, which sensitivity and specificity were 88.5% and 85.7%. All measured quantitative parameters except CTa and nZeff-a of AP were statistically significant difference between LSCC and benign laryngeal tumors. In the AP, quantitative parameters were weakly positively correlated with two kinds of tumors, especially CTa. But five quantitative parameters ( λHUv40-60keV,CTv,ICv, NICv, Zeff-v) were strongly positively in the VP,which the r values are 0.734, 0.696, 0.748, 0.691, 0.730 respectively.