Alterations in the Haemotological and Biochemical Responses of Exposed to Allium sativum Extract Against Cadmium Oxide in Male Swiss Albino Mice

Abstract

Abstract In this study following exposures of 1.5 mg/kg/day Cadmium oxide (CdO) and 1.5 mg/kg/day CdO + 300 mg/kg Allium sativum extract (mixture) were individually administered to mature in Male Swiss Albino Mice via oral gavage for 96 hours and then haemotological and biochemical responses were investigated. Hematological indices (hemoglobin (Hb), hematocrit (Hct), red blood cells (RBC), white blood cells (WBC), platelets (PLT); serum metabolites (total cholesterol, cortisol, triglyceride, glucose, total protein, bilirubin), ions (Na, K, Cl, Mg, Ca and fosfat), and enzymes; (alanine transaminase (ALT); aspartate transaminase (AST), alkaline phosphatase, (ALP) and laktat dehidrogenaz (LDH), lipase (LP)) levels were measured. CdO and mixture decreased hematological indices (except PLT); ALP and ChE, serum metabolits (except glucose and bilirubin); ions (except K, Na) while increased PLT, ALT, AST, LDH, LP, glucose, bilirubin and K ion. These increases/decreases in all hematological and biochemical parameters were generally higher in mice treated with the exposed CdO compared to the mixture of CdO and Allium sativum extract group. The study demonstrated that ameliorative effect of Allium sativum extract on metal toxicity evaluating enzyme systems, ion regulation, hematological values and metabolism as lipid, protein, and energy.