A correlational study of lipopolysaccharide-binding protein on the prognosis of septic patients in the emergency department

Abstract

Abstract Objective To explore the predictive value of lipopolysaccharide-binding protein (LBP) in assessing the risk of death in septic patients, to provide a reference for clinical work. Methods Data from 168 septic patients who were admitted to the emergency department of Beijing Chaoyang Hospital from September 2021 to September 2022 were retrospectively analyzed. SPSS25.0 software was used for data analysis and MedCalc 22.013 was applied to generate receiver operating characteristics (ROC) curves. Results A total of 54 patients were included in the non-survival group and 114 were included in the survival group. Age, respiratory rate, Acute Physiology and Chronic Health Evaluation II (APACHE II) score, Sequential Organ Failure Assessment (SOFA) score, LBP and lactate values were higher and the Glasgow Coma Scale (GCS) score and albumin were lower in the non-survival group than in the surviving group (all P < 0.001). Multivariate regression analysis showed that the APACHE II score, SOFA score, LBP and albumin were independent risk factors affecting the prognosis of septic patients. The area under the receiver operating characteristic curve (AUC) values were 0.801, 0.874 and 0.82 for LBP, APACHE II score and SOFA score, respectively, which better predicted the prognosis of septic patients. The AUC value of LBP and APACHE II score was 0.936, which was better than that of APACHE II score, SOFA score and LBP alone (P < 0.001). APACHE II + LBP had a sensitivity of 0.963 and a specificity of 0.798. Conclusion LBP is an independent risk factor affecting the outcome of septic patients and has a moderate predictive power of mortality outcome. APACHE II + LBP score has better predictive performance.