Clinical analysis of cervical cancer in the second and third trimesters of pregnancy

Abstract

Abstract Background To explore the clinical and prognostic characteristics of patients with cervical cancer in late pregnancy, and provide guidance for clinical decision-making for both doctors and patients. Methods A retrospective analysis was conducted on the clinical data of 13 cases of cervical cancer in late pregnancy treated in our hospital from 2008 to March 2022. Results The average age of the patients was 33.54 ± 4.98 years old, with 5 cases diagnosed in late pregnancy and 8 cases in mid-pregnancy. The main clinical manifestation was vaginal bleeding, and cervical biopsy confirmed the diagnoses after the patients sought medical attention. Among them, 9 patients had HPV16 infection. Eight patients underwent chemotherapy during pregnancy, and all patients underwent cesarean section to end the pregnancy. Twelve patients underwent radical surgery during cesarean section, and 1 patient underwent surgical treatment after chemotherapy 6 weeks after cesarean section. Eventually, 11 patients gave birth, while 2 patients gave up on neonatal rescue. Among them 1 patient has developed VIN I, 1 patient is lost to follow-up, and 11 patients have been cured without recurrence. Conclusion HPV16 infection before pregnancy is a high-risk factor for cervical cancer during pregnancy, and vaginal bleeding during pregnancy should be taken seriously. The prognosis is good after treatment of cervical cancer in the second and third trimesters of pregnancy.