Affiliation:
1. Third Xiangya Hospital of Central South University
Abstract
Abstract
Background
Fatigue not only has a high incidence in dialysis patients, but also has a serious adverse impact on the quality of life of dialysis patients. To compare the difference of fatigue in patients on peritoneal dialysis (PD) versus hemodialysis (HD), and explore the association of fatigue with nutrition and inflammation of patients on PD or HD. Our study will provide a basis for the prevention and intervention of fatigue in dialysis patients.
Methods
A cross-sectional study was used. Questionnaire survey and clinical data collection were performed for patients received regular PD or HD in our hospital between June 2019 and January 2020. The difference of fatigue was compared between patients on different dialysis. Pearson correlation analysis was performed to explore the association of fatigue with nutrition and inflammation, and multivariate stepwise regression was performed to explore the influencing factors of fatigue in patients on PD and HD.
Results
The prevalence of fatigue in patients on PD and HD was 97.5% and 98.9% respectively, and the percentage of patients with moderate fatigue was the highest. Fatigue in patients on PD was positively correlated with white blood cells(WBC), and negatively correlated with hemoglobin(Hb), albumin(ALB), prealbumin(PALB), and serum iron(SI). Fatigue in patients on HD was positively correlated with WBC and platelet(PLT), and negatively correlated with Hb and ALB. Multivariate stepwise regression showed that serum ALB, WBC, Hb, and SI were major influencing factors for fatigue in patients on PD, and serum ALB was the major influencing factor for fatigue in patients on HD.
Conclusions
The prevalence of fatigue is relatively high in patients on dialysis. The general fatigue and physical fatigue in patients on PD are both lower than patients on HD. Inflammation and nutrition are major influencing factors for fatigue in patients on dialysis.
Publisher
Research Square Platform LLC