Effects of Pentazocine on perioperative myocardial injury of elderly hypertensive patients

Abstract

Abstract BACKGROUNDː To observe the effect of Pentazocine on elderly hypertensive patients with preoperative and postoperative cardiac troponin I (cTnI) concentration and the occurring rate of cardiovascular events;Analysis whether Pentazocine can reduce the perioperative myocardial injury of patients with non-cardiac surgery and play a role in myocardial protection. METHODSːSelective the hip replacement under spinal anesthesia of elderly hypertensive patients of the Second Affiliated Hospital of Shanxi Medical University from Nov. 2020 to June. 2021. 79 cases were randomly divided into two group :Pentazocine group (P group, n = 39), Control group (C group, n = 40);Monitor and record the blood pressure (BP), heart rate (HR), pulse oxygen saturation (SpO2), electrocardiogram (ECG) and intraoperative adverse cardiovascular events.With the use of ELISA to determinate the preoperative and 24h-postoperative cardiac troponin I (cTnI) concentrations. RESULTSː1. When compared with the moment entering the operating room, in both group, the mean arterial pressure (MAP), heart rate (HR), pulse oxygen saturation (SpO2) have significant statistical difference (P < 0.05)with the time after the surgury; the MAP, HR, SpO2 have no difference between the two groups in both of the time (P > 0.05). 2. The incidence of adverse cardiovascular events in P group was 10.3%(4/39), it was significantly lower than that of C group27.5%(11/40),which has significant statistical difference (P < 0.05).3. the concentrations of cTnI were not different before surgery (P > 0.05) between the two groups,the cTnI concentrations in the two groups after 24h of the surgery were both higher than those before the surgery, and the increasing range of P group was significantly lower than that in C group (P < 0.05). CONCLUSIONSː 1. The hip joint replacement have significant hemodynamic changes on elderly patients with hypertension and may cause different degrees of myocardial injury;2. Pentazocine can significantly reduce the impact of the damage on patients's myocardium;The myocardial protective effect may exist.