The Efficacy of HDDPiW-jSB Solution on Docetaxel-Induced Alopecia of Rats

Abstract

Abstract Objective: Chemotherapy induced alopecia (CIA) is one of the most common side effects in cancer patients, however; it doesn’t have an effective pharmacological treatment yet. In this study we aimed to research the protective effect of HDDPiW-jSB solution on docetaxel (DTX) -induced rat alopecia model. Material and Methods: Docetaxel (10 mg/kg/week) was administered to the 6-8 months old rats for three weeks. HDDPiW-jSB solution was applied once or twice a week for 4 weeks beginning prior to one week before DTX. Rat hair follicles were evaluated with hematoxylin-eosin and immune-histochemical staining. Results: In the first stage of this study, alopecia was successfully developed by DTX application. In the second stage, application of HDDPiW-jSB solution without DTX, didn’t change the study parameters significantly. In DTX-induced alopecic rat groups’ skin samples, the solution ameliorated the anagen hair follicle count and Bcl-2 values, especially when used as twice a week. Additionally, level of Caspase 3 was decreased. HDDPiW-jSB solution was safe when applied on the skin. Conclusion: Topical HDDPiW-jSB solution could be effective and safe for the protection of DTX-induced alopecia in rat models.