Asthma and risk of gestational diabetes mellitus: a Mendelian randomization study

Author:

huang Yuzhou1,Rong Pengfei2,Wang Dan1,Lu Jianyun1

Affiliation:

1. Department of Dermatology, Third Xiangya Hospital, Central South University, Changsha

2. Department of Radiology, The Third Xiangya Hospital Central South University

Abstract

Abstract

Background Research has uncovered a significant association between asthma and the elevated risk of gestational diabetes mellitus (GDM). Yet, the specific impact of asthma on the occurrence of GDM has not been completely delineated. The objective of this research was to explore the direct impact of asthma on GDM prevalence, employing a two-sample Mendelian randomization (MR) approach. Methods This research conducted a two-sample Mendelian randomization analysis utilizing collective data from genome-wide association studies, which were available to the public and concentrated on participants of European descent. The inverse-variance-weighted (IVW) method was adopted as the primary analytic technique. To strengthen the credibility of the findings, additional analytical techniques were employed, such as MR-Egger regression, the weighted median, simple mode, and weighted mode analyses. An extensive array of sensitivity analyses was executed to ensure the reliability of the causal inferences. Results The IVW showed that genetically predicted asthma was significantly associated with an increased incidence of GDM(OR = 1.14, 95% CI = 1.04–1.24, p = 0.034).This outcome was also validated by other methods, including the weighted median (OR = 1.15, 95% CI = 1.02–1.30, p = 0.015) and simple mode (OR = 1.34, 95% CI = 1.03–1.73, p = 0.030). No heterogeneity and level pleiotropy were observed in sensitivity analyses. Conclusions The results indicate that asthma could be a contributing factor in the onset of GDM, underscoring the need for additional studies to explore the underlying connections between these conditions. It is essential to conduct more research to elucidate the causal relationships that link asthma with the emergence of GDM.

Publisher

Springer Science and Business Media LLC

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