Zimmermanne Laband syndrome and infantile systemic hyalinosis: an enigma with two separate terms with overlapping features: case report and literature review

Abstract

Abstract Background Zimmermann-Laband Syndrome (ZLS) and infantile systemic hyalinosis (ISH) are extremely rare genetic disorders characterized by various spectrum manifestations. In spite of other case reports, this case has been reported by oral medicine specialists and oral and maxillofacial surgeons with overlapping features of both syndromes. Case presentation In this study, we reported a 2-year-old female patient with gingival growth and brought about embedded erupted teeth in both jaws. The new aspect of this case report attributed to multiple papulo-nodular skin lesions barely reported by a kind of literature. Surgical excision was performed under general anesthesia. At six months of follow-up after surgery, mastication, and breathing problems were significantly improved. Aesthetic in terms of gingival appearance was ameliorated. Conclusions Although both syndromes remain an enigma for specialists to date because of their ambiguous presentations, the timely diagnosis could be crucial for prognosis and prevention of further serious surcharge. Dentists could have an important role in the diagnosis of rare disorders.