Evaluation of the influence of hypolipidemic medication on bone tissue by NMR diffusiometry

Abstract

Abstract Introduction: The ongoing concern of the medical profession regarding chronic medication is related to increasing patient adherence and compliance to treatment and reducing medication side effects. In this respect, drugs represented by fixed-dose combinations of active substances within the same tablet have emerged. Such a principle can be extrapolated by following the potential beneficial effects that a chronic medication can have on chronic pathologies affecting different systems. Material and method: The study included 48 female Albino Wistar rats, aged 16-18 months, which were divided into two groups. One group of 12 non-ovariectomized rats received no treatment, becoming a control group (NOVX-M). The ovariectomized (OVX) group was divided into 3 groups of 12 rats: no treatment, control (OVX-M), fenofibrate-treated (OVX-F) and statin-treated (OVX-S) rats. To reveal the changes, at intervals of 2, 4, 6, 8 weeks the proximal part of the femur was evaluated by NMR diffusiometry. Results: The effects of hypolipidemic medication in the absence of estrogen were evidenced, proving the beneficial effect that fenofibrate can have in preserving healthy tissue exposed to osteoporotic risk during the menopausal period. The effects of lipid-lowering medication are also influenced by the duration of administration. Conclusions: Osteoporosis and heart disease are two chronic pathologies that affect mainly female population in the second half of life, and proving the dual therapeutic potential of lipid-lowering medication may also have positive effects by increasing adherence and compliance to treatment.