Fractional Exhalation Nitric Oxide (FeNO) Changes in Cystic Fibrosis Patients Induced by Compound honey Syrup

Abstract

Abstract Objective: To evaluate the effect of Persian medicine Syrup ‘compound honey syrup (CHS)’ on Fractional exhalation Nitric Oxide (FeNO) changes in patients with Cystic Fibrosis (CF). Study design: We conducted a before-after clinical trial on 70 CF patients. All patients received classical treatments for CF along with CHS (including honey, Ginger, cinnamon, saffron, cardamom and galangal), 5-10 cc (depending on the age and weight of patients) in 100 cc of warm boiled water twice a day, 30 minutes after meals. In this clinical trial, before and 12 weeks after the start of the CHS, FeNO test was evaluated. Results: From 70 patients were enrolled, 44 patients completed this 12-week course of treatment. At the end of the study, changes in FeNO was significantly different before and after treatment (P-value < 0.05). At the end of the study, no dangerous side effects of CHS were observed. Conclusions: This study revealed that CHS can be effective as a complementary and safe drug in the medication of CF patients.