Effect of endodontic treatment on clinical outcome in type 2 diabetic patients with apical periodontitis

Abstract

Abstract Objective: The purpose of this trial was to clinically assess the effects of endodontic treatment on glycemic control in patients with type 2 diabetes mellitus (T2DM) and apical periodontitis (AP). Methodology: For present trial, AP+T2DM with patients insulin injection (n=65), AP +T2DM patients with hypoglycaemic agents (n=82), and AP patients without DM (n=86) were enrolled. After demographic characteristics and clinical examination were achieved, root canal treatment (RCT) was performed for each patients. Subjects were followed up at 2-week, 3- and 6-month. At each visit, blood samples were taken, clinical laboratory studies were performed. At 6-month follow-up, Periapical Index (PAI) score was used to assessed the periapical status.Results: A total of 237 subjects who meet the including criteria were allocated in 3 groups and 223 subjects (94.1%) completed cthe treatment and the follow-up assessments. After treatment, taking PAI into consideration, both groups showed significant improvement of AP in each group (P<0.05). Patients had a continued significant lower concentration of fasting plasma glucose (FPG) levels at follow-up except for G1 and G2 (P<0.05). A continued reduction of hemoglobin glycation (HbA1c) was observed in most of time points (P<0.05). Throughout the trial, there are also significant changes of laboratory tests of inflammatory factors in short-term.Conclusion: Endodontic therapy improved AP healing, glycemic control and systemic inflammation in patients with T2DM and/or AP in each group. However, a continued reduction in inflammatory factors and decreasing of HbA1c in short-term did not be observed in this trial.