Abstract
Objective
To investigate the effect of endometrial preparation methods prior to elective single blastocysttransfer on pregnancy outcome.
Methods
A retrospective case-control study was conducted to analyze the clinical data of 595 patients who received frozen-thawed embryo transfertreatment from January 2019 to November 2022 in the fertility center of Huzhou Maternity & Child Health Care Hospital, divided into GnRH-a+HRT group(n=213), HRT group(n=149), mNC group(n=233).
Results
The biochemical pregnancy rate and early abortion rate of mNC group were lower than GnRH-a+HRT group and HRT group (P＞0.05). The clinical pregnancy rate of mNC group was higher than GnRH-a+HRT group and HRT group (P＞0.05). The live birth rate in mNC group was significantly higher than that in GnRH-a+HRT group and HRT group (44.2% vs.34.3% vs. 36.2%, P＜0.05). The clinical pregnancy rate of mNC group was higher than GnRH-a+HRT group and HRT group (P＞0.05). The live birth rate in mNC group was significantly higher than that in GnRH-a+HRT group and HRT group (50.0% vs.34.6% vs.38.9%, P＜0.05). The early abortion rate in mNC group was significantly lower than that in GnRH-a+HRT group and HRT group (11.0% vs.26.6% vs.12.2%, P＜0.05).
Conclusion
In freeze-thaw eSBT cycles, especially in high-quality blastocyst transfer cycles, mNC has better pregnancy outcomes than GnRH-a+HRT and HRT. In clinical work, the mNC protocol was suggested to be used to elective single blastocyst transfer cycles.