Abstract
Purpose
Does the amount of gonadotrophin used during an IVF cycle affect the the number of euploid embryos by patients of different ages?
Methods
A descriptive, retrospective, observational study with 245 patients divided in two experimental groups considering the total gonadotropin dose used (≤ 3000 IU n = 150 or > 3000 IU n = 45).
Results
Patients from group ≤ 3000 IU had a shorter stimulation period, higher number of follicles, oocytes and MII retrieved, zygotes, number of blastocysts and euploid blastocysts. Regarding the kind of protocol, patients in rFSH-only group were younger, with more follicles, total and MII retrieved oocytes, zygotes, number of blastocysts and euploid blastocysts. When evaluating infertility diagnosis, the number of follicles, total and MII retrieved oocytes and zygotes were greater in the male factor group and unexplained factor compared to female plus male and mainly with female factor group. Moreover, the number of euploid blastocysts was greater in the unexplained factor group, and the female plus male group showed the lowest euploidy. A positive correlation was found between IVF outcomes and euploidy. A negative correlation was observed between embryo euploidy and maternal age and gonadotropin dose.
Conclusions
Lower doses of gonadotropin are more likely to produce more euploid blastocysts when comparing to higher dose group. The use of rFSH is related to younger patients and more euploid embryos. When female factor is present there was lower euploidy. It was also observed a positive correlation between embryo production and euploidy.