Comparing Gut Microbiota Discrepancies between Primary Sjogren's Syndrome and Healthy Controls: A Systematic Review

Author:

Zhao Qian1,Han Minghua2,Du Yage3,Zheng Jie3,Cao Zhaoming3,Lu Yao1,Lu Yanhui3ORCID

Affiliation:

1. Fifth Hospital of Shanxi Medical University

2. Shanxi Medical University

3. Peking University

Abstract

Abstract Background: The importance of the gut microbiota in primary Sjogren’s syndrome is gaining significant recognition. This systematic review summarized the previous findings on the discrepancies in gut microbiota between patients with primary Sjogren’s syndrome and healthy controls. Methods: From the establishment of the database until September 1, 2023, we conducted searches using electronic databases. We were interested in identifying specific bacterial changes between primary Sjogren’s syndrome and healthy controls as our primary outcomes. Secondary outcomes included exploring the relationship between gut microbiota and clinical parameters. To assess the quality of the included studies, we used the Newcastle-Ottawa scale. Results: A total of 9 articles were included in the analysis, comprising 504 case groups and 1313 control groups. According to two or more of the included studies, it was found that the gut microbiota of primary Sjogren’s syndrome patients was characterized by decreased butyrate-producing bacteria and increased pro-inflammatory microorganisms, as well as significantly lower levels of Actinobacteria, Firmicutes, Fusobacteria, and Proteobacteria. Furthermore, the Firmicutes/Bacteroidetes ratio was lower in patients with primary Sjogren’s syndrome than in controls. Finally, it was found that Roseburia has been shown to have a negative correlation with disease activity, as well as a negative correlation with IL-12 and IL-6. Conclusions: Patients with primary Sjogren’s syndrome exhibited reduced diversity in their gut microbiota and decreased abundance of short-chain fatty acid producers, which may offer potential therapeutic targets for future interventions. Trial registration: CRD42023421915.

Publisher

Research Square Platform LLC

Reference46 articles.

1. How rare is primary Sjögren's syndrome?;Chevet B;Joint Bone Spine,2023

2. The epidemiology of autoimmune diseases;Cooper GS;Autoimmun Rev,2003

3. Primary Sjögren syndrome-related peripheral neuropathy: A systematic review and meta-analysis;Liampas A;Eur J Neurol,2023

4. Sjögren syndrome;Brito-Zerón P;Nat Rev Dis Primers,2016

5. Current and future therapies for primary Sjögren syndrome;Seror R;Nat Rev Rheumatol,2021

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3