Electrophysiological assessmentsof different working memory states for Alzheimer's mice

Abstract

Abstract Reduced working memory is one of the important manifestations of senile dementia. Analyzing different brain regions in different states of working memory can help diagnose Alzheimer's disease and provide targets for intervention and treatment. In this study, we designed a Y-maze behavioral paradigm with voltage stimulus feedback and classified working memory states based on the selection of mice in continuous Y-maze behavior. We compared the differences in memory function between AD model mice and normal mice at the electrophysiological level. We found that: 1) the hippocampus and cingulate gyrus may play a more important role in working memory function than the frontal lobe, and the cingulate gyrus may become a new target for studying memory function; 2) Compared to the left brain region, the right brain region plays a more important role in the process of working memory; 3) Remembering the right events is more helpful for memorizing itself than remembering the incorrect events; 4) AD mice exhibit abnormalities in all three aspects mentioned above, especially abnormal brain connectivity during the correct memory process, leading to their inability to complete learning. Our research results provide an electrophysiological mechanism for the memory process, paving the way for further research into the mechanism of memory dysfunction in AD, and proposing potential intervention targets and strategies to improve memory dysfunction in AD.