Comparing and analyzing the differences between SERMs retinochoroidopathy and Macular Telangiectasia Type 2: a new pathogenic hypothesis

Abstract

Abstract Background：Because Tamoxifen Retinopathy and Macular Telangiectasia Type 2 (Mac Tel-2) have similar manifestations, many researchers are identifying and exploring the mechanisms of the two diseases. Here we report a patient with selective estrogen receptor modulators(SERMs)-induced retinochoroidopathy. And she has a history of tamoxifen and toremifene use , presenting the classic phenotype of TR. It is the first time, we use comprehensive examination to observe one patient. Case presentation: A 52-year-old woman presented gradual and progressive visual acuity decrease of both eyes about 1 year. She had received oral tamoxifen followed by toremifene for 57 months. Indocyanine green angiography(ICGA), optical coherence tomography angiography(OCTA), electrooculogram(EOG), revealed salient distinct from Mac Tel-2 phenotype in patient’s choroidal. The patient’s ocular vessels did not show any tendency to proliferate, so we serve the cessation of anti-estrogen drugs as her treatment. Conclusion: Combined with the positive results of increasing choroidal thickening, ICGA hypofluorescence, and decreased Arden ratio, SERMs-induced retinopathy is considered to be a type of retinochoroidopathy.