Affiliation:
1. Hepatogastroenterology Unit
2. Liver Unit
3. Scuola Medica Salernitana” Internal Medicine and Hepatology Unit
Abstract
Abstract
Background
Unhealthy lifestyles represent a key element fueling Non-alcoholic fatty liver disease (NAFLD) onset and worsening. We aimed to evaluate the effects of forced acute lifestyle changes on NAFLD evolution.
Methods
187 NAFLD patients were followed two years pre- and two years during the lockdown social restrictions in three Italian medical centers. For each patient, biochemical, non-invasive liver fibrosis, nutritional, and body composition data were collected.
Results
An increase in fats and carbohydrate intake associated with impaired weekly physical activity during the lockdown was demonstrated as well as an increase in body mass index and waist-hip-ratio (p < 0.0001 for all). Total cholesterol, low-density lipoprotein, high-density lipoprotein, triglycerides, glucose, insulin, homeostatic model assessment for insulin resistance, and transaminases worsened during the lockdown (glucose: p = 0.0007; p < 0.0001 for the others). Moreover, NAFLD fibrosis score, liver stiffness, and controlled attenuation parameter were also impaired during the same period (p < 0.0001 for all). The BIA evidenced an increase of fat mass (FM), and a reduction of free fat mass (FFM) and body cell mass (BCM) (p < 0.0001 for all). The lockdown overall HCC and Milan-out HCC occurrence revealed HR:2.398, p = 0.02, and HR:5.931, p = 0.008 respectively. A liver disease stage and comorbidities independent association between both the assessed outcomes and body composition analysis in terms of mean values and ‘variation (T1-T2 Δ) was demonstrated.
Conclusions
the acute lifestyle changes impacted NAFLD evolution via body composition modifications negatively influencing the HCC occurrence.
Publisher
Research Square Platform LLC
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