Effectiveness of lifestyle interventions for glycemic control among adults with Type 2 Diabetes in West Africa: a systematic review and meta-analysis protocol

Abstract

Background: Lifestyle interventions are key to the control of diabetes and the prevention of complications, especially when used with pharmacological interventions. This protocol aims to review the effectiveness of lifestyle interventions in relation to nutrition and physical activity within the West African region. This systematic review and meta analysis seeks to understand which interventions for lifestyle modification are implemented for the control of diabetes in West Africa at the individual and community level; what evidence is available on their effectiveness in improving glycaemic control; and why these interventions were effective. Methods:We will review randomised control trials and quasi-randomised control trials on physical activity and nutrition interventions within adult populations from all 16 West-African countries. Language will be restricted to English and French as these are the most widely spoken languages in the region. No other filters will be applied. Searching will involve 4 electronic databases - Pubmed, Scopus, and Africa Journals Online and Cairn.info using natural-language phrases plus reference/citation checking. Two reviewers will independently screen results according to titles and abstracts against the inclusion and exclusion criteria to identify eligible studies. Upon full text review, all selected studies will be assessed using Cochrane’s Collaboration tool for assessing the risk of bias of a study and the data will be extracted. Evidence will be synthesised narratively and statistically where appropriate. We will conduct a meta-analysis when the interventions and contexts are similar enough for pooling and compare the treatment effects of the interventions in rural to urban settings and short term to long term wherever possible. Discussion: We anticipate finding a number of studies missed by previous reviews and providing evidence of the effectiveness of different nutrition and physical activity interventions within the context of West Africa. This knowledge will support practitioners and policymakers in the design of interventions that are fit for context and purpose within the West African region. Registration: This systematic review has been registered in the International Prospective Register for Systematic Reviews - PROSPERO, with registration number CRD42023435116. All amendments to this protocol during the process of the review will be explained accordingly.