The Features Analysis of Hemoglobin Expression on Visual Information Transmission Pathway in Early Stage of Alzheimer's Disease

Author:

Li Xuehui1,Tang Pan2,Pang Xinping3,Song Xianghu1,Xiong Jing1,Yu Lei1,Liu Hui2,Pang Chaoyang1

Affiliation:

1. Sichuan Normal University

2. University of Electronic Science and Technology of China

3. Sichuan University

Abstract

Abstract

Alzheimer's Disease (AD) is a neurodegenerative disorder characterized primarily by cognitive impairment. The motivation of this paper is to explore the features of the visual information transmission pathway (V-H pathway) when AD occurs. The following features were observed: 1. Hemoglobin expression on the brain regions of the V-H pathway becomes dysregulated as AD occurs. 2. V-H pathway becomes more dysfunctional. According to the features, the following conclusion was proposed: As neurofibrillary tangles (NFTs) increase, more and more abnormal tau proteins penetrate the bloodstream and arrive at the brain regions of the V-H pathway. The hemoglobin molecules have a higher risk of attacking by abnormal tau proteins or other toxic substances. Under the attack of toxic substances, hemoglobin expression becomes more dysregulated, and the V-H pathway becomes dysfunctional. This dysfunction has an impact on early symptoms of AD, such as spatial recognition disorder and face recognition disorder.

Publisher

Springer Science and Business Media LLC

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