Risk factors of postoperative hypoalbuminemia in patients undergoing radical surgery for ovarian cancer

Abstract

Abstract Objective This study aimed to explore the perioperative risk factors for postoperative hypoalbuminemia in patients undergoing radical surgery for ovarian cancer. Methods Clinical data of 142 patients who underwent radical surgery for ovarian cancer at Ya'an People's Hospital from January 2017 to June 2022 were retrospectively analyzed. According to the albumin levels on the day of surgery, the patients were divided into a study group (serum albumin < 35g/L) and a control group (serum albumin ≥ 35g/L). The preoperative, intraoperative and postoperative data of the two groups were compared, and the perioperative risk factors for hypoalbuminemia in patients undergoing radical surgery for ovarian cancer were analyzed by univariate and multivariate binary logistic regression analysis. Results Of 142 patients, 69 (48.59%) developed hypoalbuminemia after surgery. Univariate analysis showed that increased intraoperative fluid volume, high intraoperative blood loss, substantial preoperative ascites volume, open surgery, concomitant gastrointestinal surgery, and long surgery time were related to the occurrence of hypoalbuminemia after surgery, and the difference was statistically significant (P < 0.05). Multivariate binary logistic regression analysis indicated that low preoperative albumin level, high CRP, large amount of ascites, and concomitant gastrointestinal surgery were independent risk factors for hypoalbuminemia in ovarian cancer patients after surgery (P < 0.05). Additionally, patients in the study group had higher rates of postoperative complications, longer hospital stays, and higher ICU admission rates. Conclusion The incidence of postoperative hypoalbuminemia is high in ovarian cancer patients. Low preoperative albumin level, high CRP, large amount of ascites, and concomitant gastrointestinal surgery are independent risk factors for postoperative hypoalbuminemia in patients undergoing radical surgery for ovarian cancer, which can have an adverse impact on clinical outcomes.