Efficacy of CPP-ACP GC Tooth Mousse in remineralization of teeth of Syrian orphan Children- results of a double -blind, randomized controlled clinical trial

Abstract

Abstract Objectives A double-blind randomized controlled clinical trial was undertaken to evaluate the efficacy of Casein Phosphopeptide-Amorphous Calcium Phosphate (CPP-ACP) in the remineralization of teeth of Syrian children aged 6-8 years enrolled in orphanage of the city of Damascus. Materials and Methods The study sample included 50 children randomly divided into two treatment groups to receive either CPP-ACP GC Tooth Mousse™ (Group A) or placebo (Group B) with 25 participants per group. After the application of the product in the mouth for 3 minutes, saliva samples were collected four time (T0, T1, T2, and T3) to measure the pH of saliva and the rate of salivary flow. Results There was no significant difference between group A and B in the mean value of salivary flow rate and salivary pH. However, there was significant difference between different time points in the mean value of salivary pH and salivary flow rate. Conclusion The GC Tooth Mouse (CPP-ACP) is not superior to placebo mousse at tooth remineralization according to salivary pH measure and the rate of salivary flow. Further studies are still essential to assertion findings. Trial registration: ISRCTN17509082, Registration date 22/11/2022