Aquaporin 3 modulates the risk of death conferred by dehydration in COVID-19-Reference-Cited by-同舟云学术

Aquaporin 3 modulates the risk of death conferred by dehydration in COVID-19

Published:2023-06-02 Issue: Volume: Page:
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Author:

Marks Amanda¹,Butler-Laporte Guillaume²^ORCID,Yoshiji Satoshi²,Lu Tianyuan²^ORCID,Morrison Dave³,Nakanishi Tomoko²^ORCID,Chen Yiheng²,Forgetta Vincenzo⁴,Farjoun Joseph²,Frithiof Robert⁵^ORCID,Lipcsey Miklós⁶,Zeberg Hugo⁷^ORCID,Richards J. Brent⁸^ORCID,Hultstrom Michael⁹^ORCID

Affiliation:

1. Uppsala University

2. McGill University

3. Lady Davis Institute of Medical Research

4. 5 Prime Sciences

5. Anaesthesiology and Intensive Care Medicine, Department of Surgical Sciences, Uppsala University

6. Integrative Physiology, Department of Medical Cell Biology, Uppsala University

7. Karolinska Institutet

8. Lady Davis Institute, Jewish General Hospital, McGill University

9. Anaesthesiology and Intensive Care Medicine, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.

Abstract

Abstract Severe COVID-19 has been associated with dehydration. Recently, a genetic variant near the aquaporin 3 (AQP3) water channel was associated with severe COVID-19 (rs60840586:G, Odds Ratio: 1.07, P=2.5*10-9). We show that dehydration is associated COVID-19 mortality (OR = 2.06 [95% CI = 1.62-2.65], P = 9.13*10-9), and is modulated by interaction with rs60840586:G genotype (OR = 1.95 [95% CI = 1.22-3.28], P = 0.0075).

Publisher

Research Square Platform LLC

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