The relation of CUN-BAE body fatness index with incident diabetes: a longitudinal retrospect study

Abstract

Abstract Background The Clínica Universidad de Navarra-Body Adiposity Estimator (CUN-BAE) index has been recommended as an ideal indicator of body fat and exhibited significant correlation with cardiometabolic risk factors. However, the relationship between the CUN-BAE index and incident diabetes in the Asian population remains unclear. Therefore, this longitudinal study was designed to evaluate the impact of the baseline CUN-BAE index on diabetes. Methods This retrospective longitudinal study involved 15,464 participants aged 18–79 in the NAGALA (NAfld in the Gifu Area Longitudinal Analysis) study between 2004 and 2015. The association between the baseline CUN-BAE index and diabetes incidence was tested by cox proportional-hazards regression. And the stratification analysis was further conducted to verify the robustness of the results. The ROC curve was applied to evaluate the diagnostic utility of the CUN-BAE index, and the area under the ROC curve was calculated. Results During an average of 5.4 years of follow-up, 373 (2.41%) participants were diagnosed with diabetes. A higher diabetes incidence was associated with ascending CUN-BAE quartiles (P for trend < 0.001). Each 1 standard deviation (SD) increased in CUN-BAE index was associated with a 1.4104-fold and 1.8954-fold increased risk of diabetes after adjustment for confounders in males and females, respectively (both P < 0.001). Stratification analysis demonstrated a consistent positive correlation between baseline CUN-BAE and diabetes incidence. Moreover, CUN-BAE exhibited a better capacity to predict diabetes than both BMI and WC in different genders according to ROC analysis. Conclusions The baseline CUN-BAE level was independently related to incident diabetes. Increased adiposity appraised with CUN-BAE could be used as a strong nonlaboratory predictor of incident diabetes in clinical practice.