Clinical outcomes and prognostic factors of patients with sepsis caused by intra-abdominal infection in the intensive care unit: A post-hoc analysis of a prospective cohort study in Korea

Abstract

Abstract Background: Sepsis is the most common cause of death in hospitals, and intra-abdominal infection (IAI) accounts for a large portion of the causes of sepsis. We investigated the clinical outcomes and factors influencing mortality of patients with sepsis due to IAI.Methods: This post-hoc analysis of a prospective cohort study included 2,126 patients with sepsis who visited 16 tertiary care hospitals in Korea (September 2019–February 2020). The analysis included 219 patients aged > 19 years who were admitted to intensive care units owing to sepsis caused by IAI.Results: The incidence of septic shock was 47% and was significantly higher in the non-survivor group (58.7% vs 42.3%, p=0.028). The overall 28-day mortality was 28.8%. In multivariate logistic regression, after adjusting for age, sex, Charlson comorbidity index, and lactic acid, only coagulatory dysfunction (p=0.001, odds ratio: 2.78 [1.47­–5.23]) was independently associated, and after adjusting for each risk factor, only simplified acute physiology score III (p=0.014) and continuous renal replacement therapy (p<0.001) were independently associated with higher 28-day mortality.Conclusions: Considering the independent risk factors influencing 28-day mortality, more intensive care may be needed for patients with coagulopathy than for patients with other organ dysfunctions caused by IAI.