Use of esketamine for tracheoscopic drug injection: a clinical study

Abstract

Abstract Background To assess the feasibility and safety of ketamine for tracheoscopic drug injection and identify an effective and safe anesthetic method. Methods This study included 100 patients who required painless bronchoscopy and endoscopic drug injection at our hospital from January 2020 to March 2021. Patients were randomly divided into two groups (n = 50 each): Group A received esketamine and Group B received sufentanil. During anesthesia induction, propofol and atracurium at mg/kg and 0.4 mg/kg doses were intravenously administered. Groups A and B received intravenous esketamine and sufentanil at mg/kg and 0.2 µg/kg doses, respectively. A laryngeal mask was inserted and connected to the anesthesia machine for mechanical ventilation. Anesthesia was maintained by continuous intravenous infusion of propofol at 3 mg/kg. Changes in oxygen saturation, blood pressure, surgical duration, and awake time were assessed and recorded in all patients before and after anesthesia induction. Results The anesthetic effect in Group A was significantly better than that in Group B (P < 0.05). There was no significant difference concerning respiration inhibition between Groups A and B (P > 0.05). The awake time of Group A was significantly earlier than that of Group B (P < 0.05). The effect of anesthesia on blood pressure and heart rate in Group A was lesser than that in Group B (P < 0.05). Conclusion The anesthetic effect of ketamine combined with propofol in painless bronchoscopy injection for diagnosis and treatment is good. In clinical practice, the appropriate compatible drug can be selected based on the patient’s vital signs. Hence, the patients can undergo a smooth and comfortable surgery. Trial registration Chinese Clinical Trial Registry Name of Registration: Chinese Clinical Trial Registry The registration number is：ChiCTR2000039902 Date of Registration: 22/12/2020