Lignans aid novel therapy for migraine through Network Pharmacology

Abstract

Abstract Most of the women’s daily life disturbed due to migraine attack. Till today there were lots off researches going on to treat migraine but the eminent scientists found the specific drugs to minimize the symptoms produced in the migraine attack. Network pharmacology will be the different strategy to treat migraine via networking of compound-target-pathway approach. This research looked at the molecular mechanism by which the herbal combination of Chrysanthemum indicum and Crocus sativus is effective in relieving migraine symptoms. The biomolecules of CICS were acquired from Dr. Duke's Phytochemical and Ethnobotanical and IMPPAT Databases. Active ingredients were screened by SwissADME tool and toxicity by OSIRIS tool. The migraine associated targets of active ingredients were determined by online databases. The biomolecule-target-pathway network and degree analysis were evaluated by Cytoscape software 3.9.1. Asarinin, Chrysantherol, Chrysanthetriol, Fargesin, and Crocetin were identified as key ingredients. From the 118 common targets specifically AKT1, VEGFA, TNFα, IL6, and PTGS2 were identified as top key targets based on topological parameters to treat migraineurs. Through enrichment analysis, we identified 167 significant signaling pathways. Lignans and Sesquiterpenes showed good binding affinity with more than 7.00kcal/mol in the molecular docking analysis. Pain relievers and anti-inflammatories are the cornerstones of treatment for CICS-related migraine. Multiple paths, targets, and components can be used in conjunction with the two plants. Lignan fraction having antimigraine activity in dose dependent manner, further keen research should be done with the Fargesin which provide a reference for clinical migraine management.