The Clinical Significance of Radiological Changes Associated with Gliadel® Implantation in Patients with Recurrent Glioblastoma

Abstract

Abstract Objective: Gliadel® occasionally induces edema following its implantation. We aimed to correlate such post-surgical radiological changes to its efficacy and subsequent survival.Methods: Fifty-six patients with recurrent glioblastoma were treated between 2005-2016 with Gliadel® implantation. Volumetric measurements of MRI features, including FLAIR abnormalities, tumor bulk (volume of gadolinium enhancement on T1) and resection cavity volumes over time were conducted. To assess dynamics over time, linear regression trendlines for each of these were calculated and examined to correlate with survival.Results: Median follow-up after resection was 21.5 months. Median survival post-Gliadel® implantation and overall survival since diagnosis were 12 months and 22 months, respectively. A subgroup of patients (n=6) with a transient increase in FLAIR changes volume over time survived significantly longer post-Gliadel® compared to those who did not demonstrate such change (36 vs 12 months, p=.03). Positive trends, representing overall growth in volume over time, of tumor bulk and resection cavity predicted survival in multivariate analyses (hazard ratios 7.9 and 84, p=.003 and .002, respectively).Conclusions: Increase in tumor bulk and resection cavity over time were associated with decreased survival, while transient FLAIR increase was a favorable prognostic factor. This may represent a transient inflammatory process in the tumor, possibly stemming from a presumed immune-mediated anti-tumor response.