Association between blood eosinophil count and Duchenne muscular dystrophy severity and prognosis: a retrospective cohort study

Abstract

Abstract Background: Duchenne muscular dystrophy(DMD) is a rare hereditary muscular disease. The role of eosinophils in DMD has not been clarified. This study aims to evaluate the association between peripheral blood eosinophil count and severity and prognosis of DMD. Methods: A retrospective cohort study was performed for 145 DMD patients between January 2012 and December 2020. Clinical data of 150 healthy children were collected as a control group. Logistic regression and Cox regression analyses were used to explore the influences of eosinophil count on DMD severity and prognosis. Results: Eosinophil countin DMD group was lower than the contr-ol group (Z=2.163,P=0.031). It was negatively correlated with Vign-os scale score, Spearman correlation coefficient was ρ=-0.245, P=0.040 (at admission), ρ=-0.137, P=0.032 (at follow-up); was a protec-tive factor for high Vignos scale score at admission [odds ratio (OR)=0.038,95%CI:(0.002-0.752), P=0.032] and follow-up (OR=0.033,95%CI:0.001-0.121, P=0.039). The Cox regression analysis indicated that elevated eosinophil count was correlated with better therapeuticefficacy for DMD patients [hazard ratio (HR)=1.127,95%CI:1.109-1.246, P=0.020]. Conclusion: Eosinophil count in peripheral blood was correlated with the severity of DMD. It could indicate the therapeutic efficacy and prognosis of DMD patients to a certain extent. Eosinophils may be a potentially valuable biomarker or therapeutic target for DMD.