The relationship between neutrophil-lymphocyte, platelet-lymphocyte ratio, monocyte- lymphocyte ratio and cognitive function in schizophrenia

Abstract

Abstract Schizophrenia is a psychotic disorder with unknown pathogenesis, and accompanied by varying degrees of cognitive deficits. Recent studies have shown that dysregulated immune may play an important role in schizophrenia. The aim of this study was to determine the neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and monocyte-lymphocyte ratio (MLR) in patients with schizophrenia, and explore their correlations with cognitive function. 74 patients with schizophrenia and 57 age- and gender-matched healthy controls were recruited in this study with demographic and clinical information. And blood samples were taken and cognitive function were evaluated by MCCB. All the MCCB tasks in this study were found with worse performance in patients with schizophrenia compared to healthy controls. Compare to healthy controls, patients with schizophrenia showed lower Hb levels, and higher monocytes, PLR, and MLR. Spearman correlation analysis showed Hb levels and PLR were positive and negative correlated with global cognitive function respectively. In summary, this study suggests that cognitive deficits in patients with schizophrenia is associated with dysregulated immunity and poor nutrition, which should be paid more attention in the future.