Predictive value of combined diagnosis of albumin with alkaline phosphatase or monocyte percentage on the first day of admission to hospital for the risk of death from sepsis

Abstract

Abstract Objectives: The objective of this study was to evaluate the predictive value of the combined diagnosis of albumin with alkaline phosphatase or monocyte percentage in the risk of death from sepsis. Methods: A total of 185 patients admitted to the First Affiliated Hospital of Anhui Medical University from February 2022 to January 2023 were selected as the research objects.Laboratory data is selected at admission.To identify potential independent risk factors for sepsis, a multivariate logistic regression analysis was performed.Receiver operating characteristic (ROC) curve analysis was used to evaluate the predictive accuracy of ALP, MONO% combined with ALB or the combined diagnosis of all three for mortality outcome in patients with sepsis. Results: Multiple logistic regression analysis showed that ALB, ALP, and MONO% were independent risk factors for death in patients with sepsis. As shown in Table 3, compared with the diagnosis of ALB alone. ALP or MONO% were diagnosed in combination with ALB or with all three, when all negative predictive values > 96%,the positive predictive value was increased from 36.36% to 42.11%, 46.88% and 47.05%; and the positive likelihood ratio was increased from 4.71 to 6.00 ,7.28 and 7.33 when in the case of negative likelihood ratio < 0.3 for all. Conclusions: Our study demonstrates that the combined diagnosis of ALP or MONO% with ALB or the combined diagnosis of the three had higher diagnostic value than the single diagnosis of ALB. And the results of this study provide some laboratory basis for the combined laboratory multi-indicator diagnosis of patients with sepsis at risk of death.