Crystal structure and anticancer screening of 2-(4-acetylphenylcarbamoyl)phenyl acetate-Reference-Cited by-同舟云学术

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Crystal structure and anticancer screening of 2-(4-acetylphenylcarbamoyl)phenyl acetate

Published:2022-08-10 Issue: Volume: Page:
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Author:

Mohamed-Ezzat Reham A.¹,Kariuki Benson M.²,S Aladdin M.¹

Affiliation:

1. National Research Centre

2. Cardiff University

Abstract

Abstract Aspirin-based 2-(4-acetylphenylcarbamoyl)phenyl acetate (3) has been synthesized through the reaction of 2-(chlorocarbonyl)phenyl acetate and 1-(4-aminophenyl)ethanone in the presence of triethyl amine. Assessment of anti-proliferative properties of the compound on NCI 60-cell line panel revealed remarkable to moderate anti-cancer activity. Single-crystal x-ray diffraction and spectroscopic techniques were used to validate the chemical structure of the compound.

Publisher

Research Square Platform LLC

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