COVID-19 vaccination and SARS-CoV-2 infection in early pregnancy and the risk of major congenital anomalies: a national population-based cohort study-Reference-Cited by-同舟云学术

COVID-19 vaccination and SARS-CoV-2 infection in early pregnancy and the risk of major congenital anomalies: a national population-based cohort study

Published:2022-10-06 Issue: Volume: Page:
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Author:

Wood Rachael¹,Calvert Clara²^ORCID,Carruthers Jade³,Denny Cheryl³^ORCID,Donaghy Jack³,Hopcoft Lisa⁴^ORCID,Hopkins Leanne³^ORCID,Goulding Anna³^ORCID,Lindsay Laura³,McLaughlin Terry³,Moore Emily⁵^ORCID,Taylor John³^ORCID,Loane Maria⁶,Dolk Helen⁶,Morris Joan⁷,Auyeung Bonnie⁸^ORCID,Bhaskaran Krishnan⁹^ORCID,Gibbons Cheryl³,Katikireddi Srinivasa¹⁰^ORCID,O’Leary Maureen¹¹,McAllister David¹⁰,Shi Ting¹²^ORCID,Simpson Colin¹³^ORCID,Robertson Chris¹⁴,Sheikh Aziz⁸^ORCID,Stock Sarah¹⁵^ORCID

Affiliation:

1. Public Health Scotland; Usher Institute, University of Edinburgh

2. Centre for Global Health, Usher Institute, University of Edinburgh

3. Public Health Scotland

4. Institute of Cancer Sciences, University of Glasgow

5. Public Health Scotland, Glasgow

6. Ulster University

7. University of London

8. University of Edinburgh

9. London School of Hygiene and Tropical Medicine

10. University of Glasgow

11. Public Health Scotland, Glasgow, UK

12. Usher Institute, University of Edinburgh

13. Victoria University of Wellington

14. Department of Mathematics and Statistics, University of Strathclyde, Glasgow, UK

15. University of Edinburgh Usher Institute

Abstract

Abstract Evidence on associations between COVID-19 vaccination or SARS-CoV-2 infection and the risk of congenital anomalies is limited. We conducted a national, population-based, matched cohort study to estimate the association between COVID-19 vaccination and, separately, SARS-CoV-2 infection between six weeks pre-conception and 19 weeks and six days gestation and the risk of [1] any congenital anomaly and; [2] non-genetic anomalies. Mothers vaccinated in this pregnancy exposure period mostly received an mRNA vaccine (73.7% Pfizer-BioNTech BNT162b2 and 7.9% Moderna mRNA-1273). Of the 6,731 babies whose mothers were vaccinated in the pregnancy exposure period, 153 had any congenital anomaly and 120 had a non-genetic anomaly. Primary analyses found no association between vaccination and any anomaly (adjusted Odds Ratio [aOR] = 1.01, 95% Confidence Interval [CI] = 0.83–1.24) or non-genetic anomalies (aOR = 1.00, 95% CI = 0.81–1.22). Primary analyses also found no association between SARS-CoV-2 infection and any anomaly (aOR = 1.02, 95% CI = 0.66–1.60) or non-genetic anomalies (aOR = 0.94, 95% CI = 0.57–1.54). Findings were robust to sensitivity analyses. These data provide reassurance on the safety of vaccination, in particular mRNA vaccines, just before or in early pregnancy.

Publisher

Research Square Platform LLC

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