Prognosis value and positive association of Rab1A/IL4Rα aberrant expression in gastric cancer

Abstract

Abstract Gastric cancer (GC) is the most common gastrointestinal cancer with the leading causes of cancer-related death worldwide. Many GC patients are diagnosed at the advanced stage, the five-year survival rate is unsatisfactory. Rab1A expression was significantly correlated with IL4Rα expression in non-small cell lung cancer. However, the potential correlation of Rab1A and IL4Rα in both expression and prognosis remain largely unknown in gastric cancer. In this study, Rab1A/IL-4Rα was obviously elevated in GC tissues compared with the para-cancerous tissues and Rab1A/IL-4Rα overexpression led to poor prognosis in GC patients. Rab1A expression was remarkably associated with the expression of IL-4Rα in GC tissues by IHC analysis. In addition, the mRNA expression of Rab1A was closely related with the IL-4Rα mRNA expression by qPCR in GC tissue. Furthermore, the Kaplan-Meier analysis indicated that the group with both negative of Rab1A and IL-4Rα expression had longer five-year survival rates compared with the other group. Besides, the group with both positive of Rab1A and IL-4Rα expression had a worse prognosis compared with the other group. Finally, the nomograms predicting 3 and 5-year overall survival revealed that Rab1A/IL-4Rα expression played crucial roles in predicting the prognosis of GC patients. Therefore, Rab1A/IL-4Rα may played a vital role in GC, which may provide a new visual field on the targeted therapy of GC.