A Trial of Therapy with Similac for Spit-up Formula® during pH-Multichannel Intraluminal Impedance (pH-MII) Testing for Gastro-esophageal Reflux in Former Premature Infant-Reference-Cited by-同舟云学术

A Trial of Therapy with Similac for Spit-up Formula® during pH-Multichannel Intraluminal Impedance (pH-MII) Testing for Gastro-esophageal Reflux in Former Premature Infant

Published:2024-01-16 Issue: Volume: Page:
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Author:

Hussain Naveed¹^ORCID,Washburn Susan²,Rosenkrantz Ted³,Eisenfeld Lenny⁴,Pappagallo Mariann³

Affiliation:

1. University of Connecticut Health Center

2. Connecticut Children's

3. Connecticut Children's Medical Center

4. University of Connecticut School of Medicine

Abstract

Abstract Objectives: We aimed to determine if testing with thickened and non-thickened feeds during a single pH-MII (Multiple Intraluminal Impedance) study yields clinically actionable information regarding gastroesophageal reflux disease (GERD) in infants. Methods: This was a retrospective cohort study of premature infants who underwent pH-MII testing - half performed during Mother’s Milk or Formula (MMoF) and the other half with Similac for Spit-up® formula (SSUF) feeds. Results: There were fewer total impedance events following SSUF feedings than MMoF (17.6 ± sd vs 25 ± sd, p = 0.001). There were fewer episodes of acid impedance with SSUF feeds than MMoF (5 ± sd vs 11.9 ± sd p < 0.001). Conclusions:In premature infants, SSUF reduced both total reflux episodes and the number of acid reflux episodes. We also report a novel strategy of combining GERD evaluation with a trial of therapy during a single pH-MII test.

Publisher

Research Square Platform LLC

Reference36 articles.

1. Pediatric gastroesophageal reflux clinical practice guidelines: joint recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN) and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN);Vandenplas Y;J Pediatr Gastroenterol Nutr,2009

2. Pediatric Gastroesophageal Reflux Clinical Practice Guidelines: Joint Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition;Rosen R;J Pediatr Gastroenterol Nutr,2018

3. as an Antidote to Chloroform;Bromide of Potassium;Ind Med Gaz

4. Prevalence of symptoms of gastroesophageal reflux during infancy. A pediatric practice-based survey. Pediatric Practice Research Group;Nelson SP;Arch Pediatr Adolesc Med,1997

5. Gastroesophageal reflux disease in neonates and infants: when and how to treat;Czinn SJ;Paediatr Drugs,2013