Machine Learning for Classification of Cutaneous Sebaceous Neoplasms: Implementing Decision Tree Model Using Cytological and Architectural Features

Author:

Kamyab-Hesari Kambiz1,azhari Vahidehsadat1,ahmadzade Ali2,Amoli Fahimeh Asadi3,Najafi Anahita2,Hasanzadeh Alireza2,Beikmarzehei Alireza2

Affiliation:

1. Razi Hospital

2. Tehran University of Medical Sciences

3. Farabi Eye Hospital

Abstract

Abstract Background: This observational study aimed to describe and compare histopathological, architectural, and nuclear characteristics of sebaceous lesions and utilized these characteristics to develop a predictive classification approach using machine learning algorithms. Methods: This cross-sectional study was conducted on patients with sebaceous from March 2015 to March 2019. Pathology slides were retrieved and reviewed. Two distinct pathologists assessed each slide regarding architectural and cytological attributes. A decision tree method was used to develop a prediction model. multiple models were trained on a random 80% train set, this time only using the selected variables, and mean accuracy was calculated. Results: This study assessed characteristics of 124 sebaceous tumors. Histopathological findings such as pagetoid appearance, neurovascular invasion, atypical mitosis, extensive necrotic area, poor cell differentiation, and non-lobular tumor growth pattern, as well as nuclear features such as highly irregular nuclear contour, and large nuclear size were exclusively observed in carcinomatous tumors. Among non-carcinomatous lesions, some sebaceoma cases had features like infiltrative tumor margin, and high mitotic activity which can be misleading and complicate diagnosis. Based on multiple decision tree models, the five most critical variables for lesion categorization were identified as: nuclear contour, nucleoli, peripheral basaloid cell layers, basaloid cell count, and chromatin. Conclusions: This study implemented a machine learning modeling approach to help categorize controversial sebaceous lesions based on architectural and nuclear features, optimally. However, studies of larger sample sizes are needed to ensure the accuracy of our suggested predictive model.

Publisher

Research Square Platform LLC

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3