Correlation Between TG/HDL-C Ratio or Triglyceride-Glucose Index and Mean Arterial Pressure in Patients with Myocardial Infarction: A Correlative Analytical Study

Abstract

Abstract Background: Triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio and the triglyceride-glucose (TyG) index have become novel and convenient indicators of insulin resistance (IR) and are reported to be associated with occurrence and prognosis of myocardial infarction (MI). Mean arterial pressure (MAP) is another MI indicator that affects myocardial perfusion and oxygen delivery. However, the association between TG/HDL-C ratio and TyG index with MAP in patients with MI remains unclear. The purpose of this study was to explore the correlation between TG/HDL-C ratio and TyG index with MAP in patients with MI, so as to provide new strategies to improve the prognosis of MI. Method: A total of 7341 patients with MI from January 2019 to December 2020 were enrolled to collect the general clinical data. The subjects were divided into four groups based on the quartiles of TG/HDL-C ratio and TyG index respectively. Spearman correlation analysis, univariate and multivariate linear regression analysis were employed to examine the correlation between TG/HDL-C ratio and TyG index with MAP. Results: The average age of the 7341 patients with MI was 61.39±13.13, and 62.23% were male. Spearman linear correlation analysis showed that MAP was positively associated with TG/HDL-C ratio (r=0.1218, p<0.001) and TyG index (r=0.1197, p<0.001). Univariate regression analysis showed that TG/HDL-C ratio and TyG index were positively associated with MAP in the participants. Each one unit increase in the TG/HDL-C ratio and TyG index was response for a 0.90 and 0.29 mmHg increase in MAP. Multiple regression analyses showed that MAP in the Q2, Q3 and Q4 group of the TG/HDL-C ratio were higher than those in the Q1 group (Q2 vs. Q1: β =1.42, 95%CI: 0.16-2.67; Q3 vs. Q1: β=2.04, 95%CI: 0.78-3.30; Q4 vs. Q1: β=2.55, 95%CI: 1.26-3.85). Similarly, MAP increased 1.99 mmHg in Q4 group of the TyG index when compared with the Q1 group (Q4 vs. Q1: β=1.99, 95%CI: 0.57-3.42). The association of the TyG index with MAP were more significant in male patients than in females (β=0.25 vs 0.007, p for interaction=0.023). Conclusion The TG/HDL-C ratio and TyG index were significantly positively associated with MAP in MI patients, and the association between the TyG index with MAP was more significant in male patients. Monitoring the TG/HDL-C ratio and TyG index and assessing the association between the two with MAP deserves more attention in clinical practice for the early prevention and prognosis of MI and cardiometabolic diseases.