Relationship between the expression of PSMB2 and proliferation and invasion in glioma

Abstract

Abstract There has been an upward trend in the incidence of glioma, with high recurrence and high mortality. The beta subunits of the 20S proteasome are encoded by the proteasome beta (PSMB) genes and may affect the proteasome's function in glioma, assembly and inhibitor binding. This study attempted to reveal the function of the proliferation and invasion of glioma cells, which is affectedby proteasome 20S subunit beta 2 (PSMB2). We subjected the data downloaded from the TCGA database to ROC, survival, and enrichment analyses. PSMB2 expression was verified by quantitative PCR and Western blotting to identify themRNA and protein levels. PSMB2expressionwas higher in glioma tissues, and its expression positively correlated with poor prognosis and high tumor grade.