Affiliation:
1. Yerevan State Medical University after M. Heratsi, Dental Clinic "Payl Dent"
2. Yerevan State Medical University after M. Heratsi
Abstract
Abstract
Objective
This study evaluated some physical-chemical properties of pastes for temporary filling of canals on the base of oxide zinc with eugenol and antimycotic supplements (nystatin, fluconazole, “Narine”- Lactobacillus acidophilus Er-2 strain 317/402).
Material and Methods
To evaluate the Physicochemical and antifungal properties, we studied of the time of hardening, surface structure of the hardened paste, disintegration, acidity degree (pH). In order to identify the antifungal effectiveness of the proposed paste, we compared it with other pastes, nystatin - ZnO2 (2:4), fluconazole + ZnO2 (2:4), lactobacillus lactic acid bacteria concentrate + ZnO2 (2:4), lactobacillus acidophilicus + eugenol + ZnO2 (1:1:4), nystatin + eugenol + ZnO2 (1:1:4), fluconazole + eugenol + ZnO2 (1:1:4).
Results
When studying the surface structure in pastes with acidophilic lactobacilli, microdispersed particles with a size of 1.5-5x8-15 microns were revealed; in samples of the paste with nystatin and fluconazole, macro (80 µm) and aggregated particles (70–80 µm) were detected. Lactic Acid Bacteria Concentrate + Eugenol + ZnO2 (1:1:4) provides an antifungal zone of 18.4 mm on Candida albicans (Robin) Berkhout (ATCC® 10231™) and 14.1 mm on Candida albicans (Robin) Berkhout (ATCC ®) 2091™). Studies prove antifungal effectiveness, bioavailability, and no toxicity of the proposed paste.
Conclusion
Paste based on zinc oxide and eugenol with antimycotic supplements (nystatin, fluconazole, “Narine”- Lactobacillus acidophilus Er-2 strain 317/402).)by their physical-chemical properties (hardening time, disintegration, superficial structure and acidity degree) are promising for use in temporary filling of canals. Despite promising
Publisher
Research Square Platform LLC
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