Author:
Fatullayeva Perizad Amrulla,Medjidov Ajdar Akper,Ismayilov Rayyat Huseyn,Abdullayev Asim Sabri,Lahicova Sevinc Rafiq,Abbasova Gulu Qanimet,Bayramov Mahammad Allahverdi
Abstract
Abstract
Annotation
A mononuclear complex of copper(II) with (E)-N′(3,5-di-tert-butyl-2-hydroxybenzilidene) -2-hydroxybenzohydrazide (H3sahz)2 was synthesized. The structure of the complex [Cu(H2sahz)(DMF)] was studied by elemental analysis, IR and EPR spectroscopy, and monocrystal X-ray analysis. It was shown that the complex has a square planar structure, in which the ligand is tridentate and dianionic. The coordination of the Cu(II) ion is carried out by the oxygen atom of the ditertbutyl fragment, the azomethine nitrogen atom, the hydrazide oxygen atom in the enol form, and the oxygen of the DMF molecule. In aqueous solutions, the DMF molecule in the complex is easily exchanged for a water molecule. The obtained ligand and complex possess high bactericidal and fungicidal activity. The results of these studies indicated that the metal complexes exhibit a stronger antibacterial and antifungal efficiency than their corresponding Schiff base ligands.
Publisher
Research Square Platform LLC
Reference32 articles.
1. Ashma IA, Showket Y, Subramani A, Tamilarasan R, Sasikumar G, Askar Ali SJ, Hamad. AA-L, Muthusamy K (2022) 131860 doi.org/10.1016/j.molstruc.2021.131860 D. A. Tolan, T. I.Kashar, K.Yoshizawa, & A. M. El-Nahas. Synthesis, spectral characterization, density functional theory studies, and biological screening of some transition metal complexes of a novel hydrazide–hydrazone ligand ofisonicotinic acid. Appl.Organomet Chem. (2021);35:e6205 10.1002/aoc.6205
2. Backes GL (2014) Synthesis and antifungal activity of substituted salicylaldehyde hydrazones, hydrazides and sulfohydrazides // Bioorganic & Medicinal Chemistry, – 22(17), – p.4629–4636. doi.10.1016/j.bmc.2014.07.022
3. Synthesis, structure and biological activity of cobalt(II) and copper(II) complexes of valine-derived schiff bases;J.Lv T;J Inorg Biochem,2006
4. Copper complexes of non-steroidal anti-inflammatory drugs: an opportunity yet to be realized Coord;Weder JE;Chem Rev,2002
5. Synthesis and antibacterial screening of hydrazones, Schiff and Mannich bases of isatin derivatives.Eur;Sridhar S;J Med Chem,2001