Abstract
Cervical cancer ranks as the fourth most prevalent cancer among women globally, and in recent years, there has been widespread attention on the role of lipids in tumorigenesis and development. This study utilized Mendelian Randomization (MR) to explore the causal relationship between immune cell-mediated lipids and cervical cancer risk. We have selected lipids, which are closely associated with the function of immune cells, and identified their genetic instrumental variables. Using large-scale genomic association study (GWAS) data, we genetically evaluated their levels and analyzed their correlation with the risk of cervical cancer Preliminary results suggest that triacylglycerol is significantly associated with cervical cancer risk. And elevated levels of triacylglycerol are associated with an increased risk of cervical cancer. In addition, we found that regulatory immune cells such as BAFF − R on naive − mature B cell, BAFF − R on IgD+, and BAFF − R on transitional may indirectly influence the development of cervical cancer by influencing the lipids response. Our research, employing causal inference analysis on Mendelian randomization, demonstrates the significance of immune cell-induced lipids in cervical cancer progression. These results contribute to comprehending the origins of cervical cancer and might steer the creation of upcoming preventive approaches and therapeutic tactics. Additional studies are essential to confirm these results and investigate particular biological processes.