Association between Dietary Vitamin E Intake and Cognitive Decline Among old American: National Health and Nutrition Examination Survey

Abstract

Abstract Purpose: Numerous studies have reported that vitamin E plays a key role in nervous system development and neurotransmitter production.This study aimed to investigate changes in vitamin E intake in older adults with low cognitive performance using NHANES. Methods: In this cross-sectional study, we examined a sample of 2,255 American adults aged 60 and over between 2011 and 2014. We collected dietary data by averaging two recalls for dietary use to determine vitamin E intake. We assessed cognitive function using five tests and analyzed the association between these variables using a multivariate logistic regression model. Results: A total of 2255 participants aged ≥60 years from the National Health and Nutrition Examination Survey (NHANES) for the 2011-2014 cycle were included in the analysis. Vitamin E intake was negatively associated with cognitive function. In the Z-test, each 1 mg/day increase in dietary intake of vitamin E was associated with a 6% lower likelihood of severe cognitive performance in the fully fitted model (OR = 0.94, 95% CI: 0.91~0.97) The results did not change when exposure was analyzed as a categorical variable. Compared with Q1, Q4 reduced the risk of cognitive impairment by 53% in the z-test (OR = 0.47, 95% CI: 0.33~0.67).No significant statistical interaction between the variables was found Conclusions: An increased dietary intake of vitamin E has been associated with decreased cognitive impairment in individuals over 60 years old. The dose-response curve showed an L-shaped association between dietary vitamin E intake and cognitive decline in US adults, with an inflection point of approximately 9.296 mg/day.