Identification of molecular characteristics associated with disulfidptosis and ferroptosis-related genes in breast cancer, along with immune cell infiltration Analysis and Development of a prognostic risk model

Abstract

Abstract Background Breast cancer (BRCA) is a common and highly heterogeneous malignancy with a relative poor prognosis. Disulfidptosis is a newly discovered mode of cell death induced by disulfide stress. Like ferroptosis, disulfidptosis is a novel form of programmed cell death. The goal of this research was to explore new biomarkers associated with disulfidptosis and ferroptosis that can guide the treatment of BRCA. Methods We collected expression and clinical information about BRCA patients from public database. We comprehensively characterized the relationship between disulfidptosis and ferroptosis-related genes and the molecular characteristics as well as immune cell infiltration of tumor tissue. Next, a risk model was identified based on COX regression model with least absolute shrinkage and selection operator regression (LASSO) algorithm. Besides, we evaluated the prognostic value and treatment sensitivity of various subtypes. Results Specific molecular characteristics and model possessed a promising predictive potential. Immune infiltration and treatment sensitivity analysis all showed differences between groups. Conclusions Our molecular subtypes and risk model, with strong immune prediction and prognostic prediction capabilities, are committed to guiding BRCA treatment.