Affiliation:
1. Seoul National University Hospital, Seoul National University College of Medicine
2. Seoul National University College of Medicine
Abstract
Abstract
Background Giant congenital melanocytic nevi (GCMN) are usually defined as nevi that exceed 20 cm in maximal diameter or 15% of the total body surface area. There have been reports of life-long malignant change risks arising from GCMN, leading to surgical excision of GCMN.Objective To evaluate the thickness of melanocytes according to the clinical factors of the patients to provide objective information for complete resection of the lesion.Methods Overall, 75 patients diagnosed with GCMN between 2000 and 2021 were included, and their clinical records were collected retrospectively. 117 pathologic slides obtained during excision were reviewed to measure nevus thickness. Clinical factors were assessed with a generalized estimated equation model for association with nevus thickness.Results The thickness of nevus was significantly associated with the location and size. Nevus thickness was more superficial in the distal extremity than in the head and trunk (P = 0.003 [head]; P < 0.001 [trunk]; P = 0.091 [Proximal extremity]). A nevus over 60 cm was deeper than 20–29.9 cm (P = 0.035). An interaction between size and location existed (P < 0.001).Conclusion GCMNs have deference in thickness according to location and size. Therefore, it is necessary to devise an approach optimized for each patient to treat GCMN.
Publisher
Research Square Platform LLC