Abstract
Background and objective: Patients with severe hypoxemia have a high mortality rate after failed non-invasive ventilation(NIV).Therefore,we propose utilizing pendelluft monitored by EIT to predict the failures of NIV,providing a new method for clinical practice.
Methods: This prospective observational study enrolled all patients with acute respiratory failure who were receiving NIV.The collected indices included patients' baseline characteristics,the measurement of pendelluft by EIT during the initial 24 hours of NIV after admission to the ICU,and the PaO2/FiO2 ratio.
Results: This study included 37 patients.There were no statistically significant differences in baseline characteristics between the successful and failed groups of NIV.The amplitude of pendelluft in the successful group (122.3226 (8.5493,193.8191))was significantly higher compared to the failed group (7.7538(2.6880, 25.8338))with a p-value < 0.01.The ROC curve showed the pendelluft amplitude cut-off value of 45.1124.Compared to the PaO2/FiO2,the pendelluft amplitude had a higher predictive value.
Conclusion: Monitoring pendelluft using EIT could be one of the methods for predicting the failure of NIV.