Construction and Verification of Prognosis Model Based on Autophagy-related Gene Signatures in Digestive System Tumor

Abstract

Abstract Due to the limitations of traditional histopathological diagnosis and tumor staging system, the accuracy of prognostic evaluation of digestive system tumors (DSTs) still needs to be improved. Therefore, powerful and accurate prognostic models must be developed to help clinicians optimize treatment strategies. Here, we screened 13 Prognosis-related autophagy genes (PR-ATGs) and seven independent PR-ATGs, which showcased notable prognostic value for DSTs. Upon this basis, we constructed a risk score model which assesses the prognosis of DSTs more accurately than clinicopathology. In addition, the C-index of the nomogram we constructed was 0.664. Verified by the calibration plots, there was an superior consistency between the nomogram prediction and actual observation. In Conclusion, the risk score model based on PR-ATGs and the nomogram established in conjunction with clinicopathology can better provide prognostic analysis for patients with DSTs.