Prognostic Significance of Inflammatory and Nutritional Index for Serous Ovary Cancer

Abstract

Abstract Background: The prognosis of cancer patients were related with Onodera’s prognostic nutritional index (OPNI), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and systemic immune-inflammatory index (SII). The purpose of this study is explored the prognostic value of NLR, PLR, SII and OPNI for serous ovary cancer (SOC). Patients and Methods: We retrospectively analyzed the cases of 133 patients with SOC at our institution from 2014 to 2021.Overall survival (OS) was analyzed by the Kaplan-Meier method. We performed a multivariate analysis using the Cox proportional hazard regression model to determine the independent prognostic indicators for SOC. Results: The results revealed that the optimal cut-off points of NLR, PLR, SII and OPNI were 2.3, 224.4, 747.5 and 45.5, respectively. The comparative study found that there were differences in treatment way, tumor stage, Lymph node metastasis, Albumin, NLR, PLR, SII between the high-score and low-score OPNI groups, while other indicators are not irrelevant. And OPNI, NLR, PLR, SII were related with OS, which the value of OPNI was positively correlated with OS, whereas the NLR, PLR, SII was negatively correlated with OS. The analytic result showed that OPNI was regarded as greater prognostic indicator for SOC. Conclusion: Our study found that the OPNI, NLR, SII could be a predictive and prognostic parameter for SOC.